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The Adafruit USB Host FeatherWing makes it easy to add USB Host support, especially now that TinyUSB supports it in the Arduino library as a ‘native’ interface for host support. This Wing uses the MAX3421E – a tried and true USB Host chip. It uses SPI plus an IRQ pin to send data to just about any USB device.
The Adafruit USB Host FeatherWing guide has everything you need to get started with using this FeatherWing. There’s pages for overview, pinouts, Arduino and resources for download.
Check out the full guide: Adafruit USB Host FeatherWing